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Tadaflo 5 mg, which contains the active ingredient tadalafil, is a medication used to treat erectile dysfunction (ED) in men. Like other medications in the class known as phosphodiesterase type 5 (PDE5) inhibitors, Tadaflo 5 Mg does require sexual stimulation to work effectively. Tadalafil, the active ingredient in Tadaflo, works by inhibiting the enzyme PDE5. This inhibition results in increased levels of cyclic guanosine monophosphate (cGMP), a chemical that relaxes the smooth muscle tissue in the blood vessels of the penis. While tadalafil can promote the relaxation of blood vessels and improve blood flow to the penis, it does not automatically create an erection. Instead, it enhances the natural response to sexual arousal. To achieve an erection with Tadaflo, a man typically needs to be sexually aroused or stimulated. This can include physical stimulation, visual or mental arousal, or other forms of sexual excitement. Tadaflo helps facilitate the process of achieving and maintaining an erection when sexual arousal occurs. Tadaflo is usually taken about 30 minutes to 1 hour before anticipated sexual activity. This allows time for the medication to become effective and aligns with the timing of sexual stimulation. Tadaflo has a longer duration of action compared to some other ED medications, often providing the ability to achieve and maintain an erection for up to 36 hours after taking the medication. However, it does not mean that an erection will last for 36 hours straight; sexual arousal is still required during this time frame.